ADE

(Incidence %)

Antineoplastons

Lashford et al., 2002, Temozolomide [21]

Warren et al., 2012, 06‑Benzylguanine and Temozolomide [23]

Gr. 3

Gr. 4

Gr. 3/Gr. 4

Gr. 3

Gr. 4

Hypokalemia

2.3

Hypernatremia

4.6

13.9

Fatigue

1

Somnolence

2.3

2.3

Thrombocytopenia

7

17

2

Neutropenia

12

32

Leukopenia

5

15

10

Lymphopenia

24

2

Anemia

7

Vomiting

2

2

Anorexia

<1

Infection

5

Sepsis

2

Pneumonia

2

Fever

Neuropathy

<1

Seizures

<1

Headache

2

Pain

<1